The Next Evolution in Health Optimization: Mitochondrial Stacking, Peptides, and Precision Data

The Next Evolution in Health Optimization: Mitochondrial Stacking, Peptides, and Precision Data

The Next Evolution in Health Optimization: Mitochondrial Stacking, Peptides, and Precision Data

Overview

What do you get when you combine methylene blue, PEMF, red light, hyperbaric oxygen, targeted peptide therapy, and real-time data tracking?

According to Bill Hanks, founder of huemn – Optimization + Longevity and long-time bio-optimization practitioner, you get a powerful formula for mitochondrial health, immune resilience, and clinical precision that’s already changing patient outcomes.

In a recent video interview, Bill walked us through the top three health optimization strategies he’s seeing real results from in the clinic. If you’re a health professional looking to deepen your protocols or expand your toolkit, this conversation is worth your full attention.

Here’s a closer look at what we covered.

1. The Ultimate Mitochondrial Stack

Many clinics already use modalities like PEMF, red light therapy, or hyperbaric oxygen. But what if those tools worked even better when combined in a specific order?

Bill shares a protocol that starts with methylene blue, followed by PEMF, red light, and then hyperbaric oxygen therapy. The idea is to prep the mitochondria, stimulate cellular energy, and saturate the tissues with oxygen—creating a complete arc of cellular activation and recovery.

This stack is designed to:

  • Open ion channels (PEMF)
  • Boost ATP production (red light)
  • Deliver high levels of usable oxygen (hyperbaric)
  • Support mitochondrial efficiency (methylene blue)

It’s not just about stacking therapies—it’s about using them in the right sequence to get the full physiological effect.

2. Peptides and Bioregulators in Practice

Bill also dives into his favorite peptides and bioregulators for regenerative support and immune modulation.

His go-to stack includes:

  • Thymulin (for immune resilience and inflammation control)
  • Cartilax, a bioregulator peptide used for joint repair and post-injury support
  • GLP-1 agonists like semaglutide or tirzepatide, used at moderate doses to improve metabolic function without impairing appetite or muscle retention

These tools are especially helpful for practitioners managing complex cases, chronic inflammation, or patients recovering from injury. The key takeaway here is precision—dosing and timing matter more than ever.

3. Tracking: The Most Powerful Tool in the Room

While protocols and supplements get the spotlight, Bill emphasizes that data is what makes these interventions truly effective.

Tracking gives you the ability to:

  • See what’s working
  • Adjust in real time
  • Monitor trends across labs, wearables, and symptoms
  • Make more confident clinical decisions

Whether it’s reviewing pre/post labs after peptide therapy or tracking patient response to a red light and hyperbaric routine, data provides the clarity that both patients and practitioners need.

Platforms like Heads Up Health bring these sources of data together into one central, clinician-friendly dashboard—so nothing gets missed, and you’re never flying blind.

Why This Matters for Your Practice
If you’re working in functional, integrative, concierge, or longevity care, you’ve likely seen how complex modern health optimization can be.

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Stacked therapies. New peptides. Evolving patient goals.

What sets high-performing clinics apart isn’t just access to advanced tools. It’s how they’re implemented, tracked, and tailored to each individual’s biology.

This video with Bill Hanks offers a behind-the-scenes look at protocols that are both cutting-edge and clinically grounded. Whether you’re already using these tools or just getting started, it’s a great place to get inspired and fine-tune your approach.

🎥 Watch the full conversation with Bill above to see how these strategies are being used in real clinics—and how you can bring them into yours.

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“Show Me The Data!” How Real-Time Health Data is Revolutionizing Longevity & Biohacking.

“Show Me The Data!” How Real-Time Health Data is Revolutionizing Longevity & Biohacking.

We can make micro-calibrations every day. We can test, retest, and experiment every single day. We can make changes, figure out what works, and just keep stacking them up. That’s the most exciting part of Biohacking!

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Dave Korsunsky

CEO Heads Up

Discover how real-time health data is changing healthcare.

What if you could wake up each day with the tools to steer your health with pinpoint precision?

Now, imagine unlocking your body’s full potential by harnessing the power of real-time data: measuring, tweaking, and optimizing every facet of your well-being.

In today’s fast-paced, information-rich world, optimizing your health isn’t a guessing game; it’s a data-driven strategy. David Korsunsky, founder of Heads Up, delivers a powerful message in his presentation “Show Me The Data!Revealing how cutting-edge technology empowers you to do exactly that!

This isn’t about getting by, it’s about leveling up, living longer, and feeling stronger with every decision you make.

From Systems Engineering to Biohacking

Korsunsky applies his background in optimizing high-performance IT systems to human health. Just like servers, our bodies need monitoring, fine-tuning, and optimization. This vision powers the creation of Heads Up Health—a platform built to centralize, analyze, and elevate your personal health data.

Daily Data Creates Daily Wins

The old model of annual checkups and sporadic lab work doesn’t cut it anymore. Wearables and continuous monitors offer daily health insights, giving you the power to make micro-adjustments in real time.

You don’t need to wait months to find out if a diet, supplement, or exercise program works. With tools like the Oura Ring, Dexcom CGMs, and Apple Watch, you track your progress every day. This real-time feedback turns biohacking into a personalized, results-driven experience.

The Five Biomarkers That Matter Most

There are thousands of metrics you can track, but Korsunsky focuses on five biomarkers that consistently deliver the biggest impact:

1. Heart Rate Variability (HRV)

HRV reflects the balance between your sympathetic and parasympathetic nervous systems. A higher HRV signals better stress resilience, cardiovascular health, and recovery.

Research in Frontiers in Public Health shows that higher HRV links to reduced mortality and lower risk of chronic diseases [1].

Korsunsky uses HRV daily to adjust training loads and manage stress. Since HRV is highly individualized, the goal is to improve your personal baseline—not chase someone else’s numbers.

2. Blood Glucose Levels

Stable blood sugar drives energy, sleep, hormone balance, and fat metabolism. Tools like the Dexcom Stelo let you see how food and habits affect your glucose in real time.

The CDC links poor glucose control to insulin resistance, type 2 diabetes, and cardiovascular disease [2]. Korsunsky encourages using CGMs to spot trends, correct spikes, and take control of your metabolic health.

3. Sleep Quality

Sleep fuels everything from recovery to mental clarity. Korsunsky treats it as a skill, not a given. Tools like Oura Rings reveal your sleep efficiency, heart rate trends, and more.

The Sleep Foundation highlights that consistent quality sleep boosts immune health, emotional regulation, and cognitive performance [3].

4. VO2 Max

VO2 Max measures how much oxygen your body uses during exercise. It’s a top predictor of cardiovascular endurance and long-term survival. A JAMA study shows higher VO2 Max significantly reduces mortality [4].

You can track VO2 Max with wearables or formal treadmill tests. Korsunsky recommends aiming for the fitness level of someone 10-20 years younger—and monitoring progress with every workout.

5. Muscle Mass

Muscle mass signals strength, hormone health, and resilience. Building muscle means you’re eating right, sleeping well, and training effectively.

NIH research shows that older adults with more muscle mass enjoy better mobility, metabolism, and cognitive performance [5]. Korsunsky uses DEXA scans and validated scales to track gains.

Mental Health & Breathwork: The Missing Links

Korsunsky reminds us: data isn’t just physical. Emotional health matters. Practices like breathwork and mindfulness boost HRV, improve sleep, and enhance your overall well-being.

Neuroscience backs this up. Controlled breathing helps reduce anxiety by stimulating the vagus nerve, improving focus and calm [6].

Play With Data: Make It Fun, Not Fearful

Korsunsky brings a light-hearted approach to data. Don’t stress over every number. Treat your dashboard as a sandbox for self-experimentation. Try a new routine, track your response, and adapt. That’s the essence of empowered health.

The Future of Health is Personalized

With the right data, you move beyond average. You aim for optimal. Whether you’re recovering from illness or striving for peak performance, daily data fuels continuous improvement.

Heads Up Health gives you the tools. 

Health Professionals

Want deeper insights into your patients’ health and lifestyle data?

Learn how Heads Up can help provide you the data to validate your patients’ health outcomes. Schedule a discovery call. 


Sources:

  1. Frontiers in Public Health. (2019). Heart Rate Variability and Health Outcomes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597786/
  2. CDC. (2021). Risk Factors for Type 2 Diabetes. https://www.cdc.gov/diabetes/basics/risk-factors.html
  3. Sleep Foundation. Why Do We Need Sleep? https://www.sleepfoundation.org/how-sleep-works/why-do-we-need-sleep
  4. JAMA Network. (2018). Association of Cardiorespiratory Fitness With Long-Term Mortality. https://jamanetwork.com/journals/jama/fullarticle/2713846
  5. National Institutes of Health. (2017). Skeletal Muscle and Aging. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632791/
  6. Frontiers in Psychology. (2017). Effects of Controlled Breathing on Anxiety. https://www.frontiersin.org/articles/10.3389/fpsyg.2017.00874/full

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Biohacking Tips By Don Moxley

Biohacking Tips By Don Moxley

Empowering Patients Through Personalized Biohacking: A Clinical Perspective from Don Moxley

“You can’t sit on your ass eight hours a day and think that working out for one hour is going to make up for it—it doesn’t work that way.”

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Don Moxley

HRV Researcher

In the ever-evolving landscape of health optimization, clinicians and wellness professionals are increasingly faced with a common challenge: how to empower patients with practical, data-driven strategies that genuinely move the needle on their healthspan.

In a concise but potent 4-minute video, physiologist and performance coach Don Moxley distills years of applied science into four foundational biohacks that clinicians can integrate into patient care plans starting today. These are not trendy quick fixes—they are time-tested principles grounded in physiology, behavioral science, and wearable data.

The “Four Rocks in the Jar”: Translating Insight Into Action

Moxley’s framework, known as the “Four Rocks in the Jar,” is an elegant metaphor for prioritization in health. Each “rock” represents a key lifestyle area that, when addressed, contributes to not just longevity—but quality longevity.

1. Movement: Treating Sedentary Behavior as a Health Crisis

The first pillar is movement, and Moxley is clear: sedentary lifestyles are among the most underestimated threats to modern health. As clinicians, this reframes the conversation around physical activity—not merely prescribing workouts, but coaching patients to build movement into the architecture of their daily lives.

Clinical Tip: Use wearables and step counters to prescribe movement goals, and integrate behavior-change models to sustain activity over time.

2. Nutrient Density: Moving Beyond Diets Toward Precision Nutrition

Moxley emphasizes nutrient-dense eating, urging health pros to move beyond fad diets and instead help patients assess what their bodies truly need. The use of HRV (Heart Rate Variability) as a tool to measure the impact of dietary changes offers a bridge between subjective experience and objective biofeedback.

Clinical Tip: Encourage food journaling alongside HRV tracking using platforms like Heads Up Health to visualize correlations and identify the most nourishing dietary patterns for each individual.

3. Sleep: Optimizing the Environment, Not Just the Hours

While sleep hygiene is widely discussed, Moxley makes a critical distinction—you can’t hack sleep, but you can hack your sleep environment. This reframing encourages deeper investigation into light exposure, magnesium supplementation, and even cannabinoid use when appropriate.

Clinical Tip: Audit the sleep environment and introduce sleep tracking wearables to fine-tune both quality and quantity. Avoid melatonin as a first-line intervention unless clinically indicated.

4. Light: The Overlooked Variable in Metabolic and Mental Health

Moxley introduces a game-changing perspective: light is both nutrient and toxin. Early-morning sunlight exposure is essential for resetting circadian rhythms, while blue light exposure after dark can disrupt metabolic and neurological health.

Clinical Tip: Educate patients on light hygiene. Recommend blue-light blocking glasses, dim lighting in the evening, and prioritizing morning sunlight.

Why This Matters for Health Professionals

This isn’t just biohacking—it’s applied health science. Moxley’s video is a tool clinicians can use to open conversations, initiate behavior change, and personalize care. When paired with platforms like Heads Up Health, professionals can turn subjective lifestyle advice into quantifiable, trackable outcomes.

Discovery Our New Practitioner Training:

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Biohacking Longevity With Cutting Edge Health Protocols

Biohacking Longevity With Cutting Edge Health Protocols

“We’re trying to take longevity to the next level… We have a lot of tools—it’s a 30,000 square foot facility with more biohacking technologies under one roof than probably any place in the world.”

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Dr. Beth McDougall

Chief Medical Officer Jyzen

Biohacking Longevity: A Look Inside Dr. Beth McDougall’s Cutting-Edge Health Protocols

Welcome to the future of personalized longevity and wellness, where science meets ancient wisdom under one revolutionary roof. In this blog post for Heads Up Health, we explore the insights shared by Dr. Beth McDougall on biohacking secrets and integrative medicine.

Meet the Visionary: Dr. Beth McDougall

Dr. McDougall is not only a trailblazer in integrative medicine with 26 years of experience, but also the co-founder of Jyzen, a 30,000 square foot bio-optimization center in Mill Valley, California. This facility is home to one of the most comprehensive arrays of biohacking technologies in the world.

A Personalized Protocol for Longevity

Dr. McDougall stresses that longevity protocols are deeply personal. She begins with a comprehensive health assessment—evaluating the individual’s goals, metabolic markers, hormonal balance, infectious diseases, heavy metal toxicity, gut health, and even brain function through quantitative EEG brain mapping. The goal? To uncover hidden dysfunctions and build a tailor-made strategy to optimize every layer of health.

Core Strategies for Cellular Optimization

  • Detoxification: She leverages therapies such as EVO2, phospholipid exchange, and chelation to reduce toxic load.

  • Hormonal and Metabolic Balance: From mitochondrial efficiency to receptor sensitivity, the aim is cellular rejuvenation.

  • Peptide Therapy: Dr. McDougall plans a year-long, rotating peptide protocol designed for optimal aging—not a one-size-fits-all plan but a curated rotation for those already in good health.

  • Lifestyle Enhancements: Customized diets, exercise routines, and stress management practices are key pillars of her program.

Concierge Longevity: The 2025 Vision

Rolling out in 2025, Dr. McDougall introduces a concierge medicine program that layers traditional concierge services with cutting-edge longevity protocols. Members benefit from detailed diagnostics and continuous access to all therapeutic modalities at Jyzen, guided directly by Dr. McDougall herself.

Why It Matters

This integrative approach bridges the gap between high-tech biohacking and whole-person wellness. By focusing on foundational health and leveraging breakthrough technologies, Dr. McDougall redefines aging not as a decline, but as an optimized, vibrant journey.

Stay tuned to Heads Up Health for more stories on health pioneers who are transforming the future of wellness.

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Top 3 Biohacks of 2025 By Dr. Jeff Gladd

Top 3 Biohacks of 2025 By Dr. Jeff Gladd

Top 3 Biohacks for 2025 By Dr. Jeff Gladd

⚕️Find a Trusted Practitioner – Patients need personalized guidance rather than relying solely on podcasts, books, or DIY labs. Finding the right practitioner—even if it takes a few tries—can provide clarity in a noisy health space.

🏋️‍♂️ Prioritize Muscle Health – Strength training, protein intake, and creatine are essential. Many underestimate their protein needs and the role of muscle mass in long-term health, especially when on appetite-suppressing medications like GLP-1.

🍰 Avoid Perfectionism – Balance over rigidity: it’s vital to have a solid health foundation, but also allow room to enjoy life’s pleasures like desserts and family gatherings without guilt.

Bonus Tips!

🔁 Seek Second (and Third) Opinions – Don’t settle for one voice. If the first health expert isn’t the right fit, continue the search. It’s better to navigate through a few wrong choices than stay misled.

🧮 Track with Tools Like Heads Up – Use digital health tools to assess nutrition and calorie intake. Even informed patients often underestimate protein and overestimate calories—awareness is key.

“Do not make perfection the goal… You should enjoy dessert with the family, enjoy your kid’s birthday party — we forget to enjoy life when perfection is the goal.”

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Dr. Jeff Gladd

Concierge Medicine Physician

Insights Based on Numbers

  • GLP-1 and protein deficiency: When patients use GLP-1 medications, their appetite often drops, leading to reduced protein intake. This can harm muscle mass if not managed consciously.

  • Underestimation bias: Most patients significantly underestimate their protein intake, often realizing it only after tracking with tools like Cronometer.

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