How a 4-Week Human Clinical Trial Study Helped Jigsaw MagSoothe® Back Its Promises With Oura Ring Data

How a 4-Week Human Clinical Trial Study Helped Jigsaw MagSoothe® Back Its Promises With Oura Ring Data

Overview

• Company: Jigsaw Health
• Industry: Nutritional Supplements
• Product Category: Magnesium supplement
• Target Market: Adults seeking natural support for sleep, stress, and magnesium deficiency
• Study Partner: OvationLab and Heads Up Health (data aggregation and analysis)

The Challenge

The Jigsaw Health team knew they had something special, a powdered magnesium glycinate supplement in convenient on-the-go packets designed to promote better sleep, reduce stress, and alleviate magnesium deficiency symptoms through high bioavailability.

But in a competitive supplement market, claims about sleep and wellness benefits require solid evidence. Consumers, practitioners, and retailers demand real-world proof, especially for interconnected issues like poor sleep and subclinical deficiencies tracked via wearables.

How do you demonstrate that a daily packet can deliver measurable improvements in sleep quality and related outcomes for people already monitoring their health?

Objective

To conduct a real-world human study validating the safety, efficacy, and user experience of Jigsaw MagSoothe using validated questionnaires and Oura Ring data, managed and analyzed through the Heads Up platform.

Study Design

Participants:
65 adults with persistent poor sleep quality

Inclusion Criteria:

• Self-reported interest in improving sleep quality
• Self-reported sleep quality of average or worse
• ≥4 weeks of existing Oura Ring data with Heads Up
• Any combination of: average sleep score <75 OR readiness score <75 OR sleep efficiency <75 OR deep sleep <30 min OR REM sleep <30 min

Exclusion Criteria:
Current magnesium supplement use, obstructive sleep apnea diagnosis, prescription sleep medication use, insomnia diagnosis, pregnancy or intent to become pregnant in next 3 months, undergoing chemotherapy or cancer treatment, other chronic conditions contraindicated with supplement.

Intervention:

Daily supplementation with one packet of Jigsaw MagSoothe for 4 weeks

Data Collection:

• Validated Questionnaires (PROMIS Sleep Disturbance – 6a, Perceived Stress Scale – 4, Magnesium Deficiency Questionnaire [MDQ-10]) at baseline and end
• Oura Ring metrics (total sleep time, deep sleep, REM sleep, sleep efficiency, sleep score, HRV, resting heart rate, respiratory rate, temperature deviation) throughout
• Adverse events, product satisfaction, willingness to purchase, and open-ended feedback at end

Results That Matter

Patrick Sullivan Jr.

CEO & Co-founder of Jigsaw Health.

“The data confirmed what we’d been hearing from customers: people feel more rested,
less stressed, and magnesium-replete with MagSoothe, and now we have the numbers to
back it up.” 

Key Stats at a Glance📊

Metric	Result
PROMIS – Sleep Disturbance	-10.1 pts (~17%) (p<0.0001)
Perceived Stress Scale	-2.4 pts (~34%) (p<0.0001)
Magnesium Deficiency Questionnaire	-1.5 pts (~24%) (p=0.023)
Oura: Total sleep	+12 min (7.9 → 8.1 hrs, p=0.0021)
Oura: Sleep score	+1.3 pts (p=0.011)
Oura: Respiratory rate	– 0.3 bpm (p=0.019)
Completion Rate	89.2% (Oura), 86.2% (questionnaires)
Serious Adverse Events	0
Satisfied or Very Satisfied Users	Median 85/100
Likely to Purchase	82%

Changes in Validated Questionnaire* Scores following MagSoothe Supplementation (n=56)

	Baseline	End of Study	Difference	p value
PROMIS – Sleep Disturbance – 6a	59.6	49.5	-10.1	<0.0001
Perceived Stress Scale – 4	7.1	4.7	-2.4	<0.0001
Magnesium Deficiency Questionnaire – 10	6.3	4.8	-1.5	0.023

* Lower scores indicate better health for PROMIS – Sleep Disturbance, Perceived Stress
Scale, and Magnesium Deficiency

 

Changes in Oura Scores following MagSoothe Supplementation (n=58)

	Baseline	End of Study	Difference	p value
Total Sleep (hours)	7.9	8.1	+0.2	0.0021
Deep Sleep (minutes)	57.8	59.5	+1.7	0.19
REM Sleep (minutes)	78.7	80.9	+2.2	0.052
Sleep Efficiency	82.3	82.4	+0.1	0.59
Sleep Latency (minutes)	16.3	17.7	+1.4	0.022
Sleep Score	71.4	72.7	+1.3	0.011
Heart Rate Variability (HRV)	32.7	34.2	+1.5	0.16
Resting Heart Rate (RHR)	65.9	65.6	−0.3	0.61
Temperature Deviation (°C)	−0.01	0.02	+0.03	0.058
Respiratory Rate (bpm)	15.5	15.3	−0.1	0.019
Readiness Score	75.0	75.8	+0.8	0.26

Safe, Passive, and Easy to Use

• No serious adverse events
• Only 8.7% mild GI discomfort
• 82% of participants said they would purchase MagSoothe again

What This Means for Consumers and Providers

For Individuals:

• No pills or complex routines, just a nightly packet
• Address sleep, stress, and magnesium issues naturally
• A data-backed way to optimize wellness with wearable insights

For Providers:

• Evidence-based supplement to recommend for sleep and deficiency support
• Clinically validated outcomes without pharmaceutical interventions
• High compliance and safety make it ideal for integrative care

What’s Next for Jigsaw MagSoothe®

With this study completed, Jigsaw MagSoothe® is positioned to:

• Launch new consumer education campaigns around validated sleep and stress
  benefits
• Collaborate with wellness clinics offering magnesium-focused protocols
• Enter retail and affiliate partnerships with clinical credibility to support claims
• Continue generating evidence and case studies using the Heads Up platform

Conclusion

The Jigsaw MagSoothe study is a powerful example of how nutritional interventions —sleep quality, stress relief, and magnesium repletion can be scientifically validated using consumer-grade wearables and real-world evidence tools.

Through Heads Up Health in collaboration with OvationLab, Jigsaw Health now has the data to stand behind its claims, open new markets, and build deeper trust with health-conscious consumers.

Better sleep. Less stress. Magnesium restored. All in 4 weeks. No hassle. No side effects. Just science.

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