Ferritin may be elevated due to hemochromatosis and other genetic conditions, inflammation, liver damage, haemolytic or sideroblastic anaemia. May be decreased due to poor intake, poor absorption, chronic blood loss, chronic disease or infection, progesterone birth control pills.
Increased concentrations of HS-CRP can be found in the blood after a heart attack, in sepsis, and after a surgical procedure. It is often the first evidence of inflammation or an infection in the body, with rising concentrations frequently preceding pain, fever or other clinical indicators. It is also a general marker of systemic and chronic low grade inflammation which leads to long-term tissue damage and increased mortality risk.
The PLAC test measures the amount of lipoprotein associated phospholipase (Lp-PLA2) in blood. Lp-PLA2 is an enzyme primarily associated with low density lipoprotein (LDL). LDL carries Lp-PLA2 to the coronary artery walls where it activates an inflammatory response. This makes plaque, if present, more prone to rupture. Because this enzyme is associated with causing inflammation of coronary artery walls, high levels of Lp-PLA2 would therefore seem to indicate an increased risk of heart attack or stroke. Traditional inflammatory markers, such as hsCRP, and CRP, whilst recognised as being useful systemic inflammatory markers are not as sensitive for identifying inflammation of the coronary artery walls. As a result, the PLAC Test, which is measuring levels of Lp-PLA2, serves as a specific independent coronary marker.
Bilirubin is a by-product of red blood cell breakdown and an important component of bile; functions as an antioxidant. May be elevated due to excess haemolysis, liver dysfunction, bile duct obstruction, Gilbert’s Syndrome. May be decreased due to oxidative stress, zinc deficiency.
The Cardio IQ Advanced Lipid Panel is similar to the NMR LipoProfile and both characterize lipoprotein subparticle size and number. The four most significant particle subtypes are included in this panel and include LDL particle number, Small and Medium LDL particle number, and Large HDL particle numbers. Large HDL particles are protective, so higher numbers are more desirable. For the other three, elevated levels increase your risk of developing a cardiometabolic disease. The key difference in the Cardio IQ test versus NMR is how each test characterizes subparticle size. Cardio IQ reports two size patterns, or phenotypes (A and B). Pattern B is reported when the smaller diameter particles predominate (Small LDL, specifically) and are at increased risk. Pattern A, on the other hand, suggests a predominance of Large LDL particles.
The Cardio IQ Advanced Lipid Panel is similar to the NMR LipoProfile and both characterize lipoprotein subparticle size and number. The four most significant particle subtypes are included in this panel and include LDL particle number, Small and Medium LDL particle number, and Large HDL particle numbers. Large HDL particles are protective, so higher numbers are more desirable. For the other three, elevated levels increase your risk of developing a cardiometabolic disease.
The key difference in the Cardio IQ test versus NMR is how each test characterizes subparticle size. Cardio IQ reports two size patterns, or phenotypes (A and B). Pattern B is reported when the smaller diameter particles predominate (Small LDL, specifically) and are at increased risk. Pattern A, on the other hand, suggests a predominance of Large LDL particles.
