Episode 78 – Age as a biomarker with Ryan Smith from TruDiagnostic

Podcast: Play in new window | Download

Subscribe: Apple Podcasts | RSS

Join us in today’s episode as we talk about the science of longevity, epigenetics, and its profound implications for understanding the aging process with Ryan Smith, the visionary founder of TruDiagnostic.

Ryan Smith’s journey into the realm of healthcare innovation began with a bold vision to redefine how we perceive age. With a deep understanding of epigenetics and a commitment to advancing personalized medicine, Ryan embarked on a mission to predict biological age outcomes and longevity with unprecedented accuracy. 

Through TruDiagnostic’s groundbreaking research, they have achieved an astonishing 92% accuracy rate in predicting outcomes based on biological age, revolutionizing disease prevention and treatment strategies. TruDiagnostic has developed cutting-edge algorithms to interpret methylation data, offering valuable insights into inflammatory markers, disease diagnosis, aging pace, cellular replication, and more.

Join us for this exciting episode as we discuss the amazing research that shows us the research behind longevity, quantifying the aging process, and understanding how our past experiences and traumas are stored in our DNA through an extraordinary mind-body connection. We talk about how these advancements in research can help us accurately predict biological outcomes and detect diseases such as cancer at an earlier rate.

Through TruDiagnostic’s pioneering work, we can gain a deeper understanding of how we can harness the power of epigenetics to live healthier, longer lives.

HIGHLIGHTS Of The Data Driven Podcast

[2:10] Origins of TruDiagnostic

[5:14] Longevity – Reframing the Way We See Age

[7:50] Unpacking the Science of Epigenetics

[11:53] Predicting Outcomes with Biological Age

[17:00] How TruDiagnostic Prioritizes Cost-Effective Lab Testing

[19:15] Understanding the Difference between Genetics and Epigenetics

[20:20] How Our History, Trauma, and Other Neurological Conditions Is Stored in Our DNA

[25:30] Studying the Mind-Body Connection

[31:15] Learning How We Can Age at a Better Pace

Work with Ryan Smith of TruDiagnostic:

• Website: https://trudiagnostic.com/
• Instagram: https://www.instagram.com/p/CyRY2HtORSf/
• Linkedin:  https://www.linkedin.com/in/ryan-smith-lexington-ky/
• Facebook: https://www.facebook.com/TruDiagnostic/

Use the discount code “HeadsUp” for a 20% discount off TruDiagnostics services: Lean more

Resource Mentioned:

• The Rejuvenation Olympics Website: https://rejuvenationolympics.com/ 
  
  On Biological Clocks
• OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records: https://www.biorxiv.org/content/10.1101/2023.10.16.562114v2
  
• (SymphonyAge) SystemsAge: A single blood methylation test to quantify aging heterogeneity across 11 physiological systems: https://www.biorxiv.org/content/10.1101/2023.07.13.548904v1.full.pdf
  
• DunedinPACE, a DNA methylation biomarker of the pace of aging: https://elifesciences.org/articles/73420
  
  Imprintome and Transgenerational Epigenetic Signatures
• Epigenetic Changes from Holocaust survivor children: https://www.research.va.gov/currents/1016-3.cfm#:~:text=Interestingly%2C%20Holocaust%20survivors%20and%20their,methylation%20than%20the%20control%20children.
  
• Leukocyte methylomic imprints of exposure to the genocide against the Tutsi in Rwanda: a pilot epigenome-wide analysis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672329/
  
• Fear transmitted through generations in mice: https://www.washingtonpost.com/national/health-science/study-finds-that-fear-can-travel-quickly-through-generations-of-mice-dna/2013/12/07/94dc97f2-5e8e-11e3-bc56-c6ca94801fac_story.html
  
• An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci: https://link.springer.com/article/10.1186/s13148-020-0820-0
  
  Interventional trials to Improve Biological Age
• Unveiling the Epigenetic Impact of Vegan vs. Omnivorous Diets on Aging: Insights from the Twins Nutrition Study (TwiNS): https://www.medrxiv.org/content/10.1101/2023.12.26.23300543v1
  
• Epigenetic age biomarkers and risk assessment in adult spinal deformity: a novel association of biological age with frailty and disability: https://thejns.org/spine/view/journals/j-neurosurg-spine/aop/article-10.3171-2023.10.SPINE23435/article-10.3171-2023.10.SPINE23435.xml
  
• Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions: https://www.medrxiv.org/content/10.1101/2023.09.22.23295961v1
  
• Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination: https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.819749/full#:~:text=Our%20findings%20revealed%20that%20significant,dysfunction%20induced%20by%20COVID-19